I love hitting the streets at night and looking for photo opportunities. More often than not I pump up the ISO and don't use a tripod...and yes not all the shots are succesful, but hey this is the digital era so it doesn't matter. What I am looking for is atmosphere, like these low clouds catching the glare from the city lights. That combined with the low angle gives the picture an almost rural look, though this is in the inner city.
This picture was shot at ISO 3200 at F3.5 and 1/2 second.